Amazon Policy Changes in 2024-2025 That Impact Supplement Brands
Amazon implemented the most aggressive supplement policy changes in five years. November 2024 brought mandatory third-party testing for all immune, sleep, and cognitive health supplements through only three approved organizations. Testing costs $8,000-$12,000 per SKU. Non-compliant listings were deactivated immediately—no warning, no grace period.
January 2025 fee increases added 2.5% to referral fees (now 17.5% for supplements over $20), increased FBA storage fees by 15%, and added new "low-inventory-level fees" penalizing brands with less than 28 days of stock. Combined impact: 8-12% margin compression for most supplement sellers.
The restricted ingredient list expanded to include common adaptogens and nootropics that were previously allowed. NAC (N-acetyl cysteine) was banned entirely in November 2024. DMHA and DMAE face pending restriction. Ashwagandha and rhodiola now require enhanced documentation. Brands discovered violations face immediate suppression.
How Supplement Brands Can Reduce Amazon Dependency: The Competitive Timing Advantage
Most supplement brands are paralyzed by these changes—focused on compliance, absorbing fee increases, and hoping Amazon doesn't target them next. Smart brands are using this crisis moment to build independence while competitors remain reactive. Building a DTC channel now gives you 12-18 months of competitive advantage before other sellers realize they need diversification.
The brands that will dominate 2026-2027 are the ones building owned customer acquisition channels in 2025. When the next round of restrictions hits, you'll have a business that survives regardless of Amazon's decisions.